Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder

نویسندگان

  • Li-Ming Zhang
  • Jia-Zhi Yao
  • Yang Li
  • Kai Li
  • Hong-Xia Chen
  • You-Zhi Zhang
  • Yun-Feng Li
چکیده

The dysregulation of the serotonergic system has long been recognized as an important factor underlying the pathophysiology of PTSD. To date, SSRIs have already been established as the firstline pharmacotherapeutic agents for treating acute and chronic PTSD. However, SSRIs largely have several disadvantages which limit their utility. Our previous study has also shown that administration of the total flavonoids, isolated from the extract of Xiaobuxin-Tang (XBXT, mild mind-easing decoction), comprising four Chinese medicines including Haematitum, Flos Inulae, Folium Phyllostachydis Henonis, and Semen Sojae Preparatum, exerted significant antidepressant-like effect in chronically mildly stressed rats, possibly mediated by serotonergic activation. Since the central serotonergic dysfunction is an important and well-known cause mediating the pathophysiology of trauma-related symptoms in PTSD, it is reasonable to predict that flavonoids may exert therapeutic effects on PTSD in animal models. Therefore, the present study aims to examine the effect of flavonoids in alleviating the enhanced anxiety and fear response induced in two PTSD animal models. Ser, an SSRI, was administered as a positive control. Furthermore, the changes of brain monoaminergic neurotransmitters after chronic flavonoids administration have also been assessed in SPS-treated rats.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effectiveness of Compassion Therapy on Symptoms of Posttraumatic Stress Disorder

Background: Post-Traumatic Stress Disorder is one of the most prevalent post traumatic events. The purpose of this study was to determine the efficacy of compassion therapy in improving the symptoms of post-traumatic stress disorder. Methods: The study population consisted of war veterans with post-traumatic stress disorder referring to Ebnesina Hospital in Mashhad, Iran. 30 individuals of the ...

متن کامل

IGFBP2 Produces Rapid-Acting and Long-Lasting Effects in Rat Models of Posttraumatic Stress Disorder via a Novel Mechanism Associated with Structural Plasticity

Background Posttraumatic stress disorder is an anxiety disorder characterized by deficits in the extinction of aversive memories. Insulin-like growth factor 1 (IGF1) is the only growth factor that has shown anxiolytic and antidepressant properties in human clinical trials. In animal studies, insulin-like growth factor binding protein 2 (IGFBP2) shows both IGF1-dependent and IGF1-independent pha...

متن کامل

O11: Cognitive Appraisals and Social Support in Predicting Children’s Posttraumatic Stress

Cognitive appraisals of the trauma play a key role in children’s adjustment following a traumatic event, but how these appraisals develop is not well understood. Cognitive models of posttraumatic stress disorder (PTSD) suggest that social support is a key influence on the development of appraisals, and we aimed to explore this relationship further. As predicted by cognitive models of PTSD...

متن کامل

بررسی فاکتورهای خطر قلبی عروقی و سندروم متابولیک در جانبازان جنگ با بیماری استرس مزمن ناشی از تروما و گروه شاهد آن‌ها در استان زنجان سال 91-1390

Background and Objective: It seems that war veterans are at increased risk of cardiovascular diseases due to their existing disabilities and special mental and psychological conditions. This study was performed to evaluate the risk of cardiovascular disease and the prevalence of metabolic syndrome among Iran-Iraq war veterans living in Zanjan in 2011. Materials and Methods: 360 men including 12...

متن کامل

O7: The Mechanistic Role of Sleep in Posttraumatic Stress Disorder

Around 75% of civilians have experienced at least one traumatic event in their lives, and this number is considerably higher in many parts of the world, as well as in military veterans and first responders. Of those exposed to trauma, 15-25% will develop Posttraumatic Stress Disorder (PTSD).  PTSD extracts enormous economic, health, and quality of life cost. Thus, it is critical to underst...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 2012  شماره 

صفحات  -

تاریخ انتشار 2012